GW501516

GW501516, also referred to as GW501516, is a popular compound that was first developed in the early 1990s.

Its main purpose is to prevent the formation of tumors in organs such as the prostate, colon and breast tissue.

Although it was developed for a completely different purpose, the bodybuilding community noted that it is a unique and potentially powerful SARM (Selective Androgen Receptor Modulator).

This is because it has the ability to burn fat, increase endurance and reduce the time bodybuilders need to recover.

The best part is that GW501516 is said to have no side effects.

If all of this is true, it is the best bodybuilders have ever had to offer. But is it all cracked up to be? Let’s find out.

The video below explains GW501516 in 1 minute!

WHAT IS GW501516?

Contents

  • 1 What is GW501516?
  • 2 Is GW501516 considered a SARM?
  • 3 GW501516 advantages
  • 4 Possible side effects of GW501516
  • 5 GW501516 Dosage
  • 6 Conclusion
        • 6.0.0.1 GW501516 (GW501516) Review

Pharmaceutical giant Glaxosmithkline developed GW501516 with the intention of using its benefits to treat blood vessels, heart and diabetes.

However, research on this SARM was stopped in phase 2 because the animals tested developed cancer.

However, the same results have not been observed in humans, meaning it is probably only dangerous for animals.

In addition, it would take much longer for the substance to show a cancer risk if it were tested for this effect on humans.

How was GW501516 discovered, you ask?

Well, the research community has always tried to find a suitable treatment for lifestyle diseases such as inflammation, heart disease and diabetes.

At some point, scientists were looking for a compound that could increase physical endurance while accelerating the body’s fat-burning ability. At this point they encountered the PPAR Delta path.

They found that by activating this pathway, they could immediately improve endurance, stimulate muscle growth, burn fat, and increase energy while lowering blood lipids.

GW501516 is one of the few compounds capable of binding to the PPARDelta pathway.

It is interesting to note that most of the PPARDelta is found in the muscles, which is why activation naturally leads to:

  • Improved muscle growth
  • Heart Health
  • Metabolism
  • Reduced inflammation

Based on these facts, we can conclude that GW501516 is a promising compound.

Is GW501516 considered a SARM?

No, GW501516 is NOT a SARM.

Most importantly, Selective Androgen Receptor Modulators (SARMs) are compounds that act on androgen receptors. These androgen receptors are located in muscle and bone tissues to increase muscle mass.

SARMs like LGD4033 and RAD140 were created with the intention of duplicating the activity of testosterone.

 

GW501516 is a PPARDeltaPathway activator. This means that it does not directly target androgen receptors.

GW501516 ADVANTAGES

  • Helps burn fat

PPARDelta has the ability to activate a large number of fat burning genes.

In fact, a human study was recently conducted to support these claims. It was found that GW501516 can reduce fatty acids, triglycerides and VLDL proteins.

These results were based on a double-blind, randomized, controlled trial involving 13 men who suffered from bad cholesterol and excess belly fat.

The subjects received a low dosage of just 2.5 mg per day over a period of 6 weeks.

In another study of 12 inactive men, participants received 5 to 10 mg of GW501516 per day for 12 weeks.

The results show that GW501516 was able to dramatically reduce the levels of HDL cholesterol, triglycerides and APOB.

  • Helps with muscle growth and increases endurance

Because GW501516 can activate PPARDelta pathways, it can also improve strength endurance. A study showed that the compound could increase the muscle fibers associated with peak physical performance.

  • Protects the brain

An animal study showed that GW501516 may help maintain normal blood flow to the brain. This protects the cerebral vessels from oxidative damage and stress.

It is known that PPAR activators promote the development of nerve cells. PPARDeltaPaths can also help us achieve this result.

However, in tests on rat brain cells, GW501516 was shown to have both pro- and anti-inflammatory effects.

GW501516 increased the effect of inflammatory cells such as IL6 while others reducing such as TNFalpha. It is not yet clear whether GW501516 is good or bad for the brain.

  • Helps with obesity

In another double-blind randomized controlled trial in 6 obese subjects, GW501516 was able to reverse symptoms associated with metabolic syndrome without causing side effects.

Participants received 2.5 to 10 mg of GW501516 per day for 2 weeks and showed reduced liver fat, insulin and blood lipid levels in just 2 weeks.

As if that wasn’t enough, GW501516 went through the PPARDelta pathways to prevent the effects of inflammatory substances.

Therefore, it was concluded that GW501516 may be useful in the treatment of obesity-induced insulin resistance and chronic inflammation.

This is because overweight insulin-resistant patients usually carry abdominal fat, which exposes them to higher inflammatory cytokines compared to healthy people with more PPARDelta.

Another study conducted on obese monkeys suggests thatGW501516 may reduce the risk of heart disease by reducing the occurrence of HDLC cholesterol, LDLC cholesterol, triglycerides and insulin.

In a study with mice, GW501516 was shown to prevent the overproduction of glucose by the liver while increasing insulin sensitivity. If the same results can be achieved in humans, GW501516 may be a suitable candidate for an effective treatment of type 2 diabetes and obesity.

The mice even showed improvement in muscle fiber development, which could help prevent obesity without the need for exercise. The compound may also help prevent weight gain through diet and lifestyle by speeding up fat burning in muscles.

  • Protects heart and blood vessels

There is evidence that taking GW501516 actually affects the way our blood vessels work.

A study in mice showed that it can prevent oxidative damage in blood vessels. This further helps boost vasorelaxant nitric oxide, which helps protect blood vessels from plaque buildup in the arteries.

GW501516 at lower doses has been found to provide tremendous benefits in reducing inflammation and tissue damage. If possible, this may help reduce the risk and complications associated with heart disease.

We also know that it has the ability to promote the growth of new blood vessels in actual human heart cells. This is promising news for heart sufferers, but it is only effective in limited doses. GW501516’s ability to enlarge blood vessels may also be a risk factor for cancer patients.

  • Reduces the risk of kidney inflammation

According to a study in mice, GW501516 can significantly reduce the occurrence of kidney inflammation, which can rule out kidney disease. In the study mentioned, GW501516 was able to slow down the genes associated with kidney disease.

  • It is antioxidant

In general, GW501516 is an effective anti-inflammatory agent.

It has been shown to suppress liver inflammation in animals through activation of PPARDelta. It can even suppress inflammation at the DNA level and slow down inflammatory genes. In one study, GW501516 was applied topically to mice suffering from diabetic wounds and it significantly accelerated their healing.

Using the PPARDeltaWeg, GW501516 was able to reduce inflammation and promote skin cell survival to improve the skin’s ability to heal wounds. Looking closer, the scientists found that GW501516 can also prevent the production of inflammatory molecules such as NFκB, IL6, TNFalpha and MCP1.

It didn’t stop there, however, as GW501516 also stimulated the production of beneficial antioxidant enzymes.

  • Protects the liver from damage

This compound primarily targets the liver as it is an important organ responsible for regulating fat at various stages, from burning to storage and release.

GW501516 may help lower blood sugar by forcing the liver to get its energy from fatty acids instead of glucose.

A study conducted in mice showed that GW501516 can also prevent insulin resistance by reducing the production of IL6. To prove this, researchers gave GW501516 to a group of mice eating a high fructose diet and it actually protected them from liver damage.

Further research showed that this compound has the ability to prevent liver damage in mice by killing degenerative cells.

Possible side effects of GW501516

In a study with mice that had liver disease; GW501516 has been shown to escalate liver cell death, which has the side effect of actually worsening liver damage.

It was also discovered through animal testing that GW501516 is not safe during pregnancy as it may inhibit fetal development. It has been shown to have the potential to cause cancer in rats. However, the rats received extremely high doses of GW501516 for long periods of time.

The discovery of these and other risks led GSK to pause research on the compound, although there is no evidence that it would have the same effect on human subjects.

If you are considering taking GW501516, you should consider these side effects and the lack of evidence so that you can ultimately make an informed decision.

Remember, it is only available as a research chemical.

GW501516 DOSAGE

During clinical trials, researchers used dosages of 2.5 mg to 10 mg per day for 12 weeks.

Bodybuilders and fitness enthusiasts take 10 to 20 mg of GW501516 daily.

A typical SARMs stack that includes GW501516 will last anywhere from 6 to 10 weeks. These often include ostarine and andarine to help build muscle.

You will also see many researchers stacking it with SR9009.

CONCLUSION

GW501516 is one of the most widely used compounds in the bodybuilding community. Even athletes turn to this supplement to boost their performance and maximize gains.

While we know about GW501516’s ability to increase energy, lose fat and build muscle, the only research available is based on animal studies and anecdotal evidence.

Make sure you buy GW501516 from a reputable seller. I suggest that you buy SARMs from a reputable source.

My ToGo source is Sarms4You as they deliver SARMs of the highest quality.

If you decide to use it, remember and only take it for a short period of time at the recommended dosage.